Biopharmaceutical Industry Cases & Solutions

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Liquid nitrogen (Dynamic) Vacuum Insulated Flexible Piping Systems, Vacuum Insulated Valves and Vacuum Phase Separators are needed for cryogenic storage of biological samples (Biobank), gene samples and umbilical cord blood in the biopharmaceutical industry. HL Cryogenic Equipment has 10 years and 80 projects of experience in the biopharmaceutical industry. Accumulated a lot of experience and knowledge, with the capability of "discovering customer problems", "solving customer problems" and "improving customer systems". The common problems include,

  • (Automatic) Switching of Main and Branch Lines
  • The Temperature of Liquid Nitrogen into Terminal Equipment
  • Pressure Adjustment (Reducing) and Stability of VIP
  • Cleaning Away the Possible Impurities and Ice Residue From Tank
  • Filling Time of the Terminal Liquid Equipment
  • Pipeline Precooling
  • Liquid Resistance in VIP System
  • Control Loss of Liquid Nitrogen During Discontinuous Service of the System

HL's Vacuum Insulated Pipe (VIP) is built to ASME B31.3 Pressure Piping code as a standard. Engineering experience and quality control ability to ensure the efficiency and cost-effectiveness of the customer's plant.

Related Products


  • Thermo Fisher


HL Cryogenic Equipment provides customers with the Vacuum Insulated Piping System to meet the requirements and conditions of biopharmaceutical industry:

1.Quality Management System: ASME B31.3 Pressure Piping Code.

2.VI Piping Controlled by The Vacuum Insulated Valve (VIV) Series: Including Vacuum Insulated (Pneumatic) Shut-off Valve, Vacuum Insulated Check Valve, Vacuum Insulated Regulating Valve etc. Various types of VIV can be modular combined to control the VIP as required. VIV is integrated with VIP prefabrication in manufacturer, without on-site Insulated treatment. The seal unit of VIV can be replaced easily. (HL accepts the cryogenic valve brand designated by customers, and then makes vacuum insulated valves by HL. Some brands and models of valves may not be able to be made into vacuum insulated valves.)

3.Various types of Vacuum Phase Separator meet the requirements of gas-liquid separation under different working conditions. Ensure the stability of liquid pressure and temperature in VI Piping.

4.Cleanliness, if there are additional requirements for inner tube surface cleanliness. It is suggested that customers choose BA or EP stainless steel pipes as VIP inner pipes to further reduce stainless steel spillage.

5.Vacuum Insulated Filter: Clean away the possible impurities and ice residue from tank.

6.After a few days or longer shutdown or maintenance, it is very necessary to precool the VI Piping and terminal equipment before cryogenic liquid is entered, so as to avoid ice slag after cryogenic liquid directly enters the VI Piping and terminal equipment. Precooling function should be considered in design. It provides better protection for terminal equipment and VI Piping support equipment such as valves.

7.Suit for both Dynamic and Static Vacuum Insulated (Flexible) Piping System.

8.Dynamic Vacuum Insulated (Flexible) Piping System: Consist of VI Flexible Hoses and/or VI Pipe, Jumper Hoses, Vacuum Insulated Valve System, Phase Separators and Dynamic Vacuum Pump System (including the vacuum pumps, solenoid valves and vacuum gauges etc.). The length of single VI Flexible Hose can be customized according to user’s requirements.

9.Various Connection Types: Vacuum Bayonet Connection (VBC) Type and Welded Connection can be selected. The VBC type do not need on-site insulated treatment.